comparison of the effect of omeprazole,es omeprazole and lanzoprazole on treatment of gastroesophageal reflux disease referred children aged 2 to 24 months to shahid- mofatteh clinic of yasuj-2015

Background and objective:Gastroesophageal reflux is one of the most common esophageal disordersat all age groups, especially in children, due to the transient slackness of sphincter of the lower esophagus, which results in impairment in the quality of life of the infant.Various studies have shown that proton pump inhibitors have a beneficial effect on the treatment of gastroesophageal reflux disease. The purpose of this study was to evaluate the effects of various types of proton pump inhibitors such as omeprazole, omeprazole, and lansoprazole in the treatment of reflux disease in infants. Method:This study was conducted in the form ofaclinical trial with random double-blinded allocation on 90 infants who were suffering from gastroesophageal reflux for 2 to 24 months in Yasuj. After selecting the items according to the determined indexes and completing the GERD questionnaire, the patients with a score of over 16 were included in the research sample anda completely randomized fashion they were ask to take one of the drugs at a dose of 1 mg/kg for four weeks. Besides, the questionnaire was completed at the beginning of the study and 2 and 4 weeks after treatment. The results were analyzed using ANOVA, t-test though SPSS software (version 21). Results: 90 patients selected, there were 50 boys (56%) and 40 girls (44.4%). The most common symptoms in a descending order were regurgitation (60), hiccup (47.5%), bridging (40), constant restlessness (36%) that had a significant correlation between gastroesophageal reflux and morbidity There was also a significant change in the symptoms of the disease between pre-treatment and post-treatment. Discussion and conclusion: All three drugs of omeprazole, S omeprazole and lansoprazole have been shown to be effective in controlling gastroesophageal reflux attacks in the infants. However,somparazoleshowed a significant difference with the other two drugs. It was concluded that omeprazole, omeprazole and lansoprazole have a significant effect on treatment of gastroesophageal reflux disease in 2 to 24 months old infants and of these three drugs, omeprazole showed a significant difference with the other two drugs.